Rationale: A high tumor-to-healthy-tissue uptake ratio of radiolabeled ligands is an essential prerequisite for safe and effective peptide receptor radionuclide therapy (PRRT). In the present study, we searched for novel opportunities to increase tumor-specific uptake of the radiolabeled minigastrin analogue [177Lu]Lu-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2 ([177Lu]Lu-PP-F11N), that targets the cholecystokinin B receptor (CCKBR) in human cancers. Methods: A kinase inhibitor library screen followed by proliferation and internalization assays were employed to identify compounds which can increase uptake of [177Lu]Lu-PP-F11N in CCKBR-transfected human epidermoid carcinoma A431 cells and natural CCKBR-expressing rat pancreatic acinar AR...
In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we su...
The cholecystokinin-2 receptor (CCK2R) is an attractive target in nuclear medicine due to its overex...
Item does not contain fulltextCholecystokinin-2 (CCK-2) receptors, overexpressed in cancer types suc...
The inhibition of the mammalian target of rapamycin complex 1 (mTORC1) by everolimus (RAD001) was re...
Cholecystokinin subtype 2 receptors (CCK2R) are overexpressed in several human cancers, including me...
PURPOSE: Targeting of cholecystokinin receptor expressing malignancies such as medullary thyroid car...
Contains fulltext : 70865.pdf (publisher's version ) (Closed access)PURPOSE: Radio...
AbstractThe cholecystokinin (CCK) receptor is known as a receptor that is overexpressed in many huma...
The gastrin/cholecystokinin-2 (CCK-2) receptor has been identi-fied as a possible target for peptide...
PURPOSE: Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours ...
Contains fulltext : 47567.pdf (publisher's version ) (Closed access)The aim of thi...
The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of ...
The use of conventional systemic chemotherapeutics is limited by their indiscriminate accumulation i...
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as med...
Purpose Radiolabelled cholecystokinin (CCK) and gastrin-derived peptides potentially can be used for...
In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we su...
The cholecystokinin-2 receptor (CCK2R) is an attractive target in nuclear medicine due to its overex...
Item does not contain fulltextCholecystokinin-2 (CCK-2) receptors, overexpressed in cancer types suc...
The inhibition of the mammalian target of rapamycin complex 1 (mTORC1) by everolimus (RAD001) was re...
Cholecystokinin subtype 2 receptors (CCK2R) are overexpressed in several human cancers, including me...
PURPOSE: Targeting of cholecystokinin receptor expressing malignancies such as medullary thyroid car...
Contains fulltext : 70865.pdf (publisher's version ) (Closed access)PURPOSE: Radio...
AbstractThe cholecystokinin (CCK) receptor is known as a receptor that is overexpressed in many huma...
The gastrin/cholecystokinin-2 (CCK-2) receptor has been identi-fied as a possible target for peptide...
PURPOSE: Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours ...
Contains fulltext : 47567.pdf (publisher's version ) (Closed access)The aim of thi...
The overexpression of cholecystokinin B receptor (CCKBR) in human cancers led to the development of ...
The use of conventional systemic chemotherapeutics is limited by their indiscriminate accumulation i...
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as med...
Purpose Radiolabelled cholecystokinin (CCK) and gastrin-derived peptides potentially can be used for...
In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we su...
The cholecystokinin-2 receptor (CCK2R) is an attractive target in nuclear medicine due to its overex...
Item does not contain fulltextCholecystokinin-2 (CCK-2) receptors, overexpressed in cancer types suc...