Painful intervertebral disc (IVD) degeneration is an age-related process characterized by reduced tissue osmolarity, increased catabolism of the extracellular matrix, and elevated levels of pro-inflammatory molecules. With the aging population and constantly rising treatment costs, it is of utmost importance to identify potential therapeutic targets and new pharmacological treatment strategies for low back pain. Transient receptor potential (TRP) channels are a family of Ca2+ permeable cell membrane receptors, which can be activated by multitude of stimuli and have recently emerged as contributors to joint disease, but were not investigated closer in the IVD. Based on the gene array screening, TRPC1, TRPM7, and TRPV4 were overall the most h...
The intervertebral discs are essential for upright posture and flexibility of the spine. The inner n...
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functio...
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechani...
The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartil...
Low back pain (LBP) has a high prevalence and is a major public health problem globally. Interverte...
Intervertebral disc (IVD) degeneration and consequent low back pain (LBP) are common and costly path...
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inf...
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inf...
Background Aberrant mechanical loading of the spine causes intervertebral disc (IVD) degeneration a...
Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical load...
ransient receptor potential channels (TRP channels) are cation selective transmembrane receptors wit...
Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (L...
IVD degeneration is a multifactorial pathological process associated with back pain. While biomechan...
© 2012 Yuan YuanThe Transient Receptor Potential Vanilloid 4 channel (TRPV4) is a Ca2+ permeable, no...
The molecular regulators of mechano-transduction in intervertebral disc (IVD) cells are not well und...
The intervertebral discs are essential for upright posture and flexibility of the spine. The inner n...
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functio...
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechani...
The mechanical behaviour and cellular metabolism of intervertebral discs (IVDs) and articular cartil...
Low back pain (LBP) has a high prevalence and is a major public health problem globally. Interverte...
Intervertebral disc (IVD) degeneration and consequent low back pain (LBP) are common and costly path...
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inf...
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inf...
Background Aberrant mechanical loading of the spine causes intervertebral disc (IVD) degeneration a...
Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical load...
ransient receptor potential channels (TRP channels) are cation selective transmembrane receptors wit...
Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (L...
IVD degeneration is a multifactorial pathological process associated with back pain. While biomechan...
© 2012 Yuan YuanThe Transient Receptor Potential Vanilloid 4 channel (TRPV4) is a Ca2+ permeable, no...
The molecular regulators of mechano-transduction in intervertebral disc (IVD) cells are not well und...
The intervertebral discs are essential for upright posture and flexibility of the spine. The inner n...
Transient receptor potential (TRP) channels play an important role in sensory and nonsensory functio...
The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechani...