Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy
- Errico G.
- Gagliotti C.
- Monaco M.
- Masiero L.
- Gaibani P.
- Ambretti S.
- Landini M. P.
- D'Arezzo S.
- Di Caro A.
- Parisi S. G.
- Palu G.
- Vespasiano F.
- Morsillo F.
- Moro M. L.
- Procaccio F.
- Ricci A.
- Grossi P. A.
- Pantosti A.
- Nanni Costa A.
- Farina C.
- Vailati F.
- Gesu G.
- Vismara C.
- Arghittu M.
- Colombo R.
- Torresani E.
- Rossi L.
- Conaldi P. G.
- Gona F.
- Cambieri P.
- Marone P.
- Venditti C.
- Fernandez A. G.
- Mancini C.
- Cusi M.
- De Angelis L. H.
- Fossati L.
- Finarelli A. C.
- De Cillia C.
- Sangiorgi G.
- Pinna A. D.
- Stella F.
- Viale P.
- Colledan M.
- Platto M.
- Bonizzoli M.
- Peris A.
- Torelli R.
- Vesconi S.
- Cibelli E.
- De Carlis L.
- De Gasperi A.
- Ravini M.
- Carrinola R.
- Coluccio E.
- Dondossola D.
- Rossi G.
- Santambrogio L.
- Tosi D.
- Feltrin G.
- Rago C.
- Cillo U.
- Da Riva A.
- Rea F.
- Sparacino V.
- Bertani A.
- Canzonieri M.
- Gridelli B.
- Mularoni A.
- Spada M.
- Carrara E.
- D'Armini A. M.
- Paladini P.
- Adorno D.
- Valeri M.
- Caprio M.
- Di Ciaccio P.
- Puoti F.
- Berloco P.
- D'Auria B.
- Maldarelli F.
- Paglialunga G.
- Pugliese F.
- Rossi M.
- Venuta F.
- Amoroso A.
- Giacometti R.
- Rinaldi M.
- Salizzoni M.
DOIAbstract
Objectives: A prospective cohort study was conducted in Italy in order to describe the microbiologic aspects of colonization/infection by carbapenemase-producing Enterobacteriaceae (CPE) in donors and recipients of lung and liver transplants and the possible CPE transmission from donors to recipients. Methods: Between 15 January 2014 and 14 January 2015, all recipients of solid organ transplants (SOT) at ten lung and eight liver transplantation centres and the corresponding donors were enrolled. Screening cultures to detect CPE were performed in donors, and screening and clinical cultures in recipients with a 28-day microbiologic follow-up after receipt of SOT. Detection of carbapenemase genes by PCR, genotyping by multilocus sequence typin...
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