A simple and effective binomial block based pulse sequence capable of suppressing multiple NMR signals

A binomial-like block based multiple suppression NMR pulse sequence, termed MULTI-GATE-FSB, that is simple to implement with outstanding suppression performance for multiple solvent signals (or multiple resonances) is investigated. The sequence was tested on two water–alcohol solvent systems, and a standard lysozyme sample, with suppression of three or four regions (though it is extendable to any number of regions). The suppression of all solvent signals was possible in the alcohol–water systems tested with both long and short recycle delays and without the requirement for lengthy presaturation pulses. Such a sequence holds promise not only for LC–NMR applications and solvent suppression but for multiple suppression applications in general (e.g., analysis of impurities/components)