O-1918 does not alter food intake, body weight or adiposity but reduces appetite hormones and increases certain pro-inflammatory cytokines in a diet induced obesity model

Introduction: O-1918 is a synthetic compound structurally similar to the plant constituent cannabidiol, and is an antagonist for GPR55 and GPR18. While the role of GPR18 in obesity is unknown, GPR55 knockout mice have increased adiposity and insulin resistance. In humans, the expression of GPR55 is increased in visceral fat and positively correlated with obesity and T2D. Both receptors are classified as putative cannabinoid receptors. The endocannabinoid system is involved in regulating energy homeostasis. Therefore modulation of these receptors may be a useful obesity target. Aim: To determine the role that O-1918 has on the regulation of body weight and circulating hormones and cytokines