High through-put liquid chromatography : mass spectrometry requires new strategies for the management of fluid at the interface

The ever increasing demand on regulation in bioanalysis, whether that be the routine testing of athletes to ascertain compliance with drug regulation, or the analysis of metabolites in biological samples to determine rapid response to drug treatment protocols, or any of the many other tests that regulation authorities demand, have, as such, placed a very high reliance on analytical testing. Many of these analyses are undertaken using chromatographic separations coupled with mass spectrometry, and there is substantial evidence that suggests HPLC–MS is the quintessential analytical technique for quantification and sample identification employed in bioanalysis. Furthermore, there will be continued growth in this area of analytical sciences because of the substantial information obtained, and as such, the mass spectrometer may well end up being the ‘go-to’ detector