Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

We have synthesised, characterised and examined the cytotoxicity of [(1,10- phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 ± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane) platinum(II)]2+ (1.5 ± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+(0.15 ± 0.06 μM) and cisplatin (0.43 ± 0.06 μM)