Cellular and biochemical studies support a role for all five human RecQ helicases in DNA replication, however their specific functions during this process are unclear. In my thesis, I investigated the in vivo association of the five human RecQ helicases with three well-characterized human replication origins. I showed that only RECQ1 and RECQ4 associate with replication origins in a cell cycle-regulated fashion in unperturbed cells, while other RecQ helicases interact with replication origins only under replication perturbed conditions. Under endogenous conditions, RECQ4 is recruited to origins at late G1 after ORC and MCM complex assembly, while RECQ1 and additional RECQ4 are loaded at origins at the onset of S phase when licensed origins ...
RecQ DNA helicases function during DNA replica-tion and are essential for the maintenance of genome ...
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in pro...
International audienceThe RecQ helicases are conserved from bacteria to humans and play a critical r...
Cellular and biochemical studies support a role for all five human RecQ helicases in DNA replicatio...
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefor...
The RecQ helicases are involved in several aspects of DNA metabolism. Five members of the RecQ famil...
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable inte...
Since the original observations made in James German's Laboratory that Bloom's syndrome cells lackin...
SummaryThree (BLM, WRN, and RECQ4) of the five human RecQ helicases are linked to genetic disorders ...
The progression of replication forks can be slowed down or paused by various external and internal f...
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its...
AbstractThe RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key role...
RecQ helicases play an important role in preserving genomic integrity, and their cellular roles in D...
The vertebrate RECQL4 (RECQ4) gene is thought to be the ortholog of budding yeast SLD2. However, Rec...
RecQ helicases maintain chromosome stability by resolving a number of highly specific DNA structures...
RecQ DNA helicases function during DNA replica-tion and are essential for the maintenance of genome ...
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in pro...
International audienceThe RecQ helicases are conserved from bacteria to humans and play a critical r...
Cellular and biochemical studies support a role for all five human RecQ helicases in DNA replicatio...
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefor...
The RecQ helicases are involved in several aspects of DNA metabolism. Five members of the RecQ famil...
Understanding the molecular and cellular functions of RecQ helicases has attracted considerable inte...
Since the original observations made in James German's Laboratory that Bloom's syndrome cells lackin...
SummaryThree (BLM, WRN, and RECQ4) of the five human RecQ helicases are linked to genetic disorders ...
The progression of replication forks can be slowed down or paused by various external and internal f...
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its...
AbstractThe RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key role...
RecQ helicases play an important role in preserving genomic integrity, and their cellular roles in D...
The vertebrate RECQL4 (RECQ4) gene is thought to be the ortholog of budding yeast SLD2. However, Rec...
RecQ helicases maintain chromosome stability by resolving a number of highly specific DNA structures...
RecQ DNA helicases function during DNA replica-tion and are essential for the maintenance of genome ...
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in pro...
International audienceThe RecQ helicases are conserved from bacteria to humans and play a critical r...