Spinal motoneurons innervating skeletal muscle were amongst the first neurons shown to require the presence of their target cells to develop appropriately. Isolated embryonie chick and rat motoneurons have been used to identify neurotrophic factors and cytokines capable of supporting the survival of developing motoneurons. Such factors include ciliary neurotrophic factor (CNTF), which is present physiologically in high amounts in myelinating Schwann cells of peripheral nerves, and brain-derived neurotrophic factor (BDNF) which is synthesized in skeletal muscle and, after peripheral nerve lesion. in Schwann cells. These factors have been further analyzed for their physiological significance in maintaining motoneuron function in vivo, and for...
Ciliary neurotrophic factor (CNTF) is expressed in high quantities in Schwann cells of peripheral ne...
Neurotrophins play a crucial role in the regulation of survival and maintenance of specific function...
Motoneurons innervating the skeletal musculature were among the first neurons shown to require the p...
Motoneuron diseases represent a m&jor challenge to modern neurology, yet their clinical manifestatio...
We have demonstrated that the extensive degener ation of motoneurons in the rat facial nucleus after...
We have demonstrated that the extensive degener-ation of motoneurons in the rat facial nucleus after...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic...
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic...
CILIARY neurotrophic factor (CNTF) supports the survival of embryonic motor neurons in vitro and in ...
Glial cell line-derived neurotrophic factor (GDNF), a member of the TG F-beta superfamily, has been ...
Glial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons i...
The period of natural cell death in the development of rodent motor neurons is followed by a period ...
Ciliary neurotrophic factor (CNTF) is expressed in high quantities in Schwann cells of peripheral ne...
Neurotrophins play a crucial role in the regulation of survival and maintenance of specific function...
Motoneurons innervating the skeletal musculature were among the first neurons shown to require the p...
Motoneuron diseases represent a m&jor challenge to modern neurology, yet their clinical manifestatio...
We have demonstrated that the extensive degener ation of motoneurons in the rat facial nucleus after...
We have demonstrated that the extensive degener-ation of motoneurons in the rat facial nucleus after...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
We have previously shown that glial cell line-derived neurotrophic factor (GDNF), in addition to pro...
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic...
Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic...
CILIARY neurotrophic factor (CNTF) supports the survival of embryonic motor neurons in vitro and in ...
Glial cell line-derived neurotrophic factor (GDNF), a member of the TG F-beta superfamily, has been ...
Glial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons i...
The period of natural cell death in the development of rodent motor neurons is followed by a period ...
Ciliary neurotrophic factor (CNTF) is expressed in high quantities in Schwann cells of peripheral ne...
Neurotrophins play a crucial role in the regulation of survival and maintenance of specific function...
Motoneurons innervating the skeletal musculature were among the first neurons shown to require the p...