Add to ORKGBy means of indirect immunofluorescence analysis we investigated the effect of HIV -1 infection on HLA class I surface antigens. We report here that in CD4\(^+\) HeLa cells, in H9 cells, and in peripheral T Iymphocytes HLA class I antigens are down regulated following infection with HIV -1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-l in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced
HIV infection of CD4+ peripheral blood lymphocytes leads to a loss of MHC dass I molecules on the su...
ribute to HIV dis-determin raction b believed to to the length of the asymptomatic period [4]. In pa...
The setpoint of viral RNA concentration (viral load [VL]) during chronic human immunodeficiency viru...
HIV-1 is capable of infecting many different cell types that express the CD4 molecule. In vivo and i...
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surfa...
AbstractTo avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from t...
(A) Infectious molecular clones were assessed for ability to downregulate HLA-C for 3 individuals: C...
(A) Viral isolates were generated from ART-suppressed individuals and infected co-cultured Molt-4 ce...
This thesis focuses on the impact of HLA class I restricted T cells on HIV-1 disease progression. It...
Abstract Background HIV-1 infection is associated with profound dysfunction of myeloid dendritic cel...
International audienceHuman immunodeficiency virus type 1 (HIV-1) has evolved elaborate ways to evad...
It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C...
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of th...
Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during pr...
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of th...
HIV infection of CD4+ peripheral blood lymphocytes leads to a loss of MHC dass I molecules on the su...
ribute to HIV dis-determin raction b believed to to the length of the asymptomatic period [4]. In pa...
The setpoint of viral RNA concentration (viral load [VL]) during chronic human immunodeficiency viru...
HIV-1 is capable of infecting many different cell types that express the CD4 molecule. In vivo and i...
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surfa...
AbstractTo avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from t...
(A) Infectious molecular clones were assessed for ability to downregulate HLA-C for 3 individuals: C...
(A) Viral isolates were generated from ART-suppressed individuals and infected co-cultured Molt-4 ce...
This thesis focuses on the impact of HLA class I restricted T cells on HIV-1 disease progression. It...
Abstract Background HIV-1 infection is associated with profound dysfunction of myeloid dendritic cel...
International audienceHuman immunodeficiency virus type 1 (HIV-1) has evolved elaborate ways to evad...
It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C...
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of th...
Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during pr...
HIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of th...
HIV infection of CD4+ peripheral blood lymphocytes leads to a loss of MHC dass I molecules on the su...
ribute to HIV dis-determin raction b believed to to the length of the asymptomatic period [4]. In pa...
The setpoint of viral RNA concentration (viral load [VL]) during chronic human immunodeficiency viru...