We evaluate the Wightman function, the mean field squared and the vacuum expectation value of the energy–momentum tensor for a scalar field with the Robin boundary condition on a spherical shell in the background of a constant negative curvature space. For the coefficient in the boundary condition there is a critical value above which the scalar vacuum becomes unstable. In both the interior and the exterior regions, the vacuum expectation values are decomposed into the boundary-free and sphere-induced contributions. For the latter, rapidly convergent integral representations are provided. In the region inside the sphere, the eigenvalues are expressed in terms of the zeros of the combination of the associated Legendre function and its deriva...