Syndrome of perimenopausal melatonin deficiency is a new marker of women reproductive system aging

The aim of our study was to determine a complex of risk factors of the perimenopausal melatonin deficiency syndrome (SPDM) in postmenopausal women and women during menopausal transition suffering from climacteric syndrome. The study involved 278 women. They were divided into two groups: I group included 246 menopausal women and II group included 32 women during the menopausal transition. The Medical History was collected, the menopausal index, and anthropometric measures were determined. The study was conducted with a help of the test questionnaire for melatonin deficiency (TQMD), the women’s health questionnaire (WHQ), and detection of the level of 6- sulfatoxymelatonin (6-SOMT) in urine. According to the obtained data, risk factors of SPDM in women during the menopausal transition are the chronological age increment, overweight, and the reduction of the estradiol level. The leading risk factors of SPDM in postmenopausal women are the chronological age increment, overweight with visceral type of obesity and changes in the hormonal profile. Thus, SPDM is a new clinical and laboratory marker of aging of the female reproductive system, an important screening tool for detecting the development of CC in women during the menopausal transition and menopausal women