We investigate the relevance of the instanton-induced determinantal 't Hooft interaction to the eta-nucleon coupling g(nNN) within the framework of a three-flavor linear sigma model in the OZI-rule-respecting basis {((s) over bars),(1/root2 + (d) over bard)}. Instantons, in combination with the spontaneous breaking of chiral symmetry, are shown to provide the major mechanism for the ideal mixing between pseudoscalar strange and non-strange quarkonia. As long as 't Hooft's interaction captures most of the basic features of the axial QCD gluon anomaly, we identify the anomaly as the main culprit for the appearance of octet flavor symmetry in the anomalous sectors of the pseudoscalar (and axial vector) mesons. Within this context, unitary spin...