Expanding the range of ZNF804A variants conferring risk of psychosis
- Steinberg, S.
- Mors, O.
- Olason, P.
- Ophoff, R.A.
- Cichon, S.
- Gudjorsdottir, I.H.
- Pietiläinen, O.P.
- Nyegaard, M.
- Tuulio-Henriksson, A.
- Ingason, A.
- Hansen, T.
- Athansiu, L.
- Borglum, A.D.
- Luvisaari, J.
- Lonnqvist, J.
- Paunio, T.
- Hartmann, A.
- Jürgens, G.
- Nordentoft, M.
- Hougaard, D.
- Norgaard-Pdersen, B.
- Breuer, R.
- Möller, J.H.
- Gustafsson, O.
- Giegling, I.
- Glenthoj, B.
- Rasmussen, H.B.
- Mattheisen, M.
- Bitter, I.
- Rethelyi, J.M.
- Sigundsson, T.
- Fossdal, R.
- Thorsteinsdottir, U.
- Ruggeri, M.
- Werge, T.
- Tosato, S.
- Strengman, E.
- GOUP Kiemeney, L.A.
- Melle, I.
- Djurovic, S.
- Abramova, L.
- Kaleda, V.
- Walshe, M.
- Bramon, E.
- Vassos, E.
- Mortensen, P.B.
- Li, T.
- Fraser, G.
- Walker, N.
- Toulopoulou, T.
- Yoon, J.
- Freimer, N.B.
- Cantor, R.M.
- Murray, R.
- Kong, A.
- Golimbet, V.
- Andreassen, O.A.
- Jönsson, E.G.
- Terenius, L.
- Agartz, I.
- Petursson, H.
- Nöthen, M.M.
- Rietschel, M.
- Peltonen, L.
- Rujescu, D.
- Collier, D.A.
- Stefansson, H.
- Sigurdsson, E.
- St Clair, D.
- Stefansson, K.
- Thorgeirsson, T.E.
- Böttcher, Y.
DOIAbstract
A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10(-8)) associated with schizophrenia earlier. However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10(-7), and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10(-8). In this study, using 5164 schizophrenia cases and 20,709 controls, we replicated the association with schizophrenia (odds ratio OR = 1.08, P = 0.0029) and, by adding bipolar disorder patients, we also confirmed the association wit...
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