Quine’s argument for a naturalized epistemology is routinely perceived as an argument from despair: traditional epistemology must be abandoned because all attempts to deduce our scientific theories from sense experience have failed. In this paper, I will show that this picture is historically inaccurate and that Quine’s argument against first philosophy is considerably stronger and subtler than the standard conception suggests. For Quine, the first philosopher’s quest for foundations is inherently incoherent; the very idea of a self-sufficient sense datum language is a mistake as there is no science-independent perspective from which to validate science. I will argue that a great deal of the confusion surrounding Quine’s argument is prompte...