Bovine seminal ribonuclease (BS-RNase) is a homologue of RNase A with special biological properties, including potent immunosuppressive activity. A mutant BS-RNase was created in which His-119, the active-site residue that acts as a general acid during catalysis, was changed to an aspartic acid. H119D BS-RNase formed a dimer with quaternary structure similar to that of the wild-type enzyme but with values of k(cat) and k(cat.)/K-m for the cleavage of UpA [uridylyl(3' --> 5')adenosine] that were 4x10(3)-fold lower. The mutant protein also demonstrated dramatically decreased immunosuppressive, anti-tumour, aspermatogenic, and embryotoxic activities. The catalytic activity of BS-RNase is therefore necessary for its special biological propertie...
Bovine seminal ribonuclease exists in the native state as an equilibrium mixture of a swapped and an...
Seminal RNase (BS-RNase), a ribonuclease from bovine seminal vesicles, is a homodimeric enzyme with ...
It has been previously shown that the antitumor action of bovine seminal ribonuclease (BS-RNase) is ...
Bovine seminal ribonuclease (BS RNase) displays immunosuppressive and antitumor activities on mammal...
Bovine seminal ribonuclease (BS-RNase) is an unusual homolog of RNase A. Isolated from bulls as a di...
Bovine seminal ribonuclease (BS-RNase) is a homolog of RNase A with special biological properties th...
Bovine seminal ribonuclease (BS-RNase), a homolog of bovine pancreatic ribonuclease (RNase A), is is...
Bovine seminal RNAase (BS-RNAase), an unusually dimeric member of the pancreatic-like ribonuclease s...
Bovine seminal RNase, an unusual member of the pancreatic-like ribonuclease superfamily, is also a m...
ABSTRACT: Bovine seminal ribonuclease (RNase) binds, melts, and (in the case of RNA) catalyzes the h...
ABSTRACT: Bovine seminal ribonuclease (BS-RNase) is a homologue of bovine pancreatic ribonuclease (R...
Bovine seminal RNase (BS-RNase) is a dimeric member of the pancreatic-like ribonuclease superfamily,...
Seminal RNase (BS-RNase), a ribonuclease from bovine seminal vesicles, is a homodimeric enzyme with ...
Bovine seminal ribonuclease (BS-RNase), a dimeric homolog of bovine pancreatic ribonuclease A (RNase...
Bovine seminal ribonuclease (BS-RNase) is a 27 kDa homodimeric enzyme and a member of the pancreatic...
Bovine seminal ribonuclease exists in the native state as an equilibrium mixture of a swapped and an...
Seminal RNase (BS-RNase), a ribonuclease from bovine seminal vesicles, is a homodimeric enzyme with ...
It has been previously shown that the antitumor action of bovine seminal ribonuclease (BS-RNase) is ...
Bovine seminal ribonuclease (BS RNase) displays immunosuppressive and antitumor activities on mammal...
Bovine seminal ribonuclease (BS-RNase) is an unusual homolog of RNase A. Isolated from bulls as a di...
Bovine seminal ribonuclease (BS-RNase) is a homolog of RNase A with special biological properties th...
Bovine seminal ribonuclease (BS-RNase), a homolog of bovine pancreatic ribonuclease (RNase A), is is...
Bovine seminal RNAase (BS-RNAase), an unusually dimeric member of the pancreatic-like ribonuclease s...
Bovine seminal RNase, an unusual member of the pancreatic-like ribonuclease superfamily, is also a m...
ABSTRACT: Bovine seminal ribonuclease (RNase) binds, melts, and (in the case of RNA) catalyzes the h...
ABSTRACT: Bovine seminal ribonuclease (BS-RNase) is a homologue of bovine pancreatic ribonuclease (R...
Bovine seminal RNase (BS-RNase) is a dimeric member of the pancreatic-like ribonuclease superfamily,...
Seminal RNase (BS-RNase), a ribonuclease from bovine seminal vesicles, is a homodimeric enzyme with ...
Bovine seminal ribonuclease (BS-RNase), a dimeric homolog of bovine pancreatic ribonuclease A (RNase...
Bovine seminal ribonuclease (BS-RNase) is a 27 kDa homodimeric enzyme and a member of the pancreatic...
Bovine seminal ribonuclease exists in the native state as an equilibrium mixture of a swapped and an...
Seminal RNase (BS-RNase), a ribonuclease from bovine seminal vesicles, is a homodimeric enzyme with ...
It has been previously shown that the antitumor action of bovine seminal ribonuclease (BS-RNase) is ...