Kinolonski antimikrobni lijekovi

Quinolones are an important group of powerful synthetic broad spectrum antimicrobial drugs which are active against gram-negative and gram-positive microorganisms as well as some atypical pathogens and anaerobes. This review contains information about historical development, chemical structures, mechanism of action and activity spectrum of these drugs. Therapeutic use, pharmacokinetics, common adverse effects, interactions and methods of determination in bodily fluids are also covered. Understanding of properties of individual agents in this group is necessary for appropriate and safe administration to each patient. Growing incidence of microbial resistance to these drugs calls for rational use in future