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Most drugs used in treatment of breastfeeding mothers are tentatively safe. The exposure of breastfeeding mothers to drug or other xenobiotics will generally result in the transfer of these substances in human milk in low concentrations. The knowledge about medicines and their characteristics (pKa, solubility in water and lipids, the size of the molecule, oral bioavailability, toxicity, effects on milk production, t1/2) helps healthcare professionals in appropriate drug prescribing, in providing an useful information and patient tracking for possible drug effect in infant. The risk of adverse drug reactions is highest in children below 2-3 months, and in breastfeeding mothers who are on psychoactive drugs. According to the FDA classification, drugs used in breastfeeding are classified into five categories of L1 till L5. Drugs in the category L5, like radioactive isotopes, ACE inhibitors, estrogens, bromocriptine are strictly contraindicated in breastfeeding