Synthesis of new hydrazone derivatives of vitamine B6, pyridine-4-carbaldehyde and 2-quinolinecarbaldehyde

U radu su sintetizirani hidrazonski derivati vitamina B6, piridin-4-karbaldehida te 2-kinolinkarbaldehida (1-15). Za sintezu su korišteni fenil-hidrazin te supstituirani fenil-hidrazini: 2,4-dinitrofenil-hidrazin, 4-klorfenil-hidrazin, 4-fluorfenil-hidrazin, 4-metilfenil-hidrazin. Reakcije su izvedene u dva različita otapala, acetonu i etanolu kako bi se ispitao utjecaj polarnosti i apsorpcijske moći otapala na iskorištenje reakcije. Sinteze su se odvijale pod utjecajem mikrovalnog zračenja, ekološki prihvatljivijom metodom kojom se u znatno kraćem vremenu može dobiti željeni produkt. U radu je ispitano kako mikrovalno zračenje kao jedno od alternativnih metoda sinteze i odabir otapala utječu na kemijska iskorištenja u odnosu na konvencionalne metode sinteze hidrazonskih derivata. Dobiveni rezultati uspoređeni su s istraživanjima drugih autora koji su slične ili iste hidrazone dobili klasičnom organskom sintezom.Hydrazone derivatives of vitamin B6, pyridine-4-carbaldehyde and 2-quinolinecarbaldehyde (1-15) were synthesized in this thesis. Phenyl-hydrazine and substituted phenyl-hydrazines were used for the synthesis: 2,4-dinitrophenyl-hydrazine, 4-chlorophenyl-hydrazine, 4-fluorophenyl-hydrazine, 4-methylphenyl-hydrazine. Reactions were performed in two different solvents, acetone and ethanol to examine the effect of solvent polarity and absorption power on reaction yield. The syntheses were carried out under the influence of microwave radiation, a more environmentally friendly method by which the desired product can be obtained in a much shorter time. The thesis examines how microwave radiation as one of the alternative methods of synthesis and the choice of solvent affect the chemical yields compared to conventional methods of synthesis of hydrazone derivatives. The obtained results were compared with the researches of other authors who obtained similar or the same hydrazones by classical organic synthesis