Add to ORKG© 2018 The Authors Existing computational models applied in the protein structure prediction process do not sufficiently account for the presence of the aqueous solvent. The solvent is usually represented by a predetermined number of H2O molecules in the bounding box which contains the target chain. The fuzzy oil drop (FOD) model, presented in this paper, follows an alternative approach, with the solvent assuming the form of a continuous external hydrophobic force field, with a Gaussian distribution. The effect of this force field is to guide hydrophobic residues towards the center of the protein body, while promoting exposure of hydrophilic residues on its surface. This work focuses on the following sample proteins: Engrailed homeodomain (...
The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathi...
A description of many biological processes requires knowledge of the 3-D structure of proteins and, ...
Simulations employing an explicit atom description of proteins in solvent can be computationally exp...
Existing computational models applied in the protein structure prediction process do not sufficientl...
Water environment is conditioning all biological activity. The folding process can not be treated wi...
The fuzzy oil drop model suggests that the tertiary conformation of a protein – particularly a globu...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
Knowledge-based models for protein folding assume that the early-stage structural form of a polypept...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
In this paper we show that the fuzzy oil drop model represents a general framework for describing th...
This diagram demonstrates the core concept of the fuzzy oil drop (FOD) model, which posits the exist...
Abstract Knowledge-based models for protein folding assume that the early-stage structural form of a...
The role of the environment in amyloid formation based on the fuzzy oil drop model (FOD) is discusse...
Understanding and modelling protein folding remains a key scientific and engineering challenge. Two ...
The role of the environment in amyloid formation based on the fuzzy oil drop model (FOD) is discusse...
The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathi...
A description of many biological processes requires knowledge of the 3-D structure of proteins and, ...
Simulations employing an explicit atom description of proteins in solvent can be computationally exp...
Existing computational models applied in the protein structure prediction process do not sufficientl...
Water environment is conditioning all biological activity. The folding process can not be treated wi...
The fuzzy oil drop model suggests that the tertiary conformation of a protein – particularly a globu...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
Knowledge-based models for protein folding assume that the early-stage structural form of a polypept...
The aqueous environment is a pervasive factor which, in many ways, determines the protein folding pr...
In this paper we show that the fuzzy oil drop model represents a general framework for describing th...
This diagram demonstrates the core concept of the fuzzy oil drop (FOD) model, which posits the exist...
Abstract Knowledge-based models for protein folding assume that the early-stage structural form of a...
The role of the environment in amyloid formation based on the fuzzy oil drop model (FOD) is discusse...
Understanding and modelling protein folding remains a key scientific and engineering challenge. Two ...
The role of the environment in amyloid formation based on the fuzzy oil drop model (FOD) is discusse...
The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathi...
A description of many biological processes requires knowledge of the 3-D structure of proteins and, ...
Simulations employing an explicit atom description of proteins in solvent can be computationally exp...