Background: The intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that is key to cancer progression and evolution. We aimed to assess the degree of microenvironmental heterogeneity in breast cancer and correlate this with genomic and clinical parameters. Methods and Findings: We developed a quantitative measure of microenvironmental heterogeneity along three spatial dimensions (3-D) in solid tumors, termed the tumor ecosystem diversity index (EDI), using fully automated histology image analysis coupled with statistical measures commonly used in ecology. This measure was compared with disease-specific survival, key mutations, genome-wide copy ...
Because every cancer is different, different cancer patients can benefit from different treatments. ...
Breast cancer is a very heterogeneous disease. This heterogeneity can be observed at many levels, in...
Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic...
Background The intra-tumor diversity of cancer cells is under intense investigation; however, little...
The tumor microenvironment is pivotal in influencing cancer progression and metastasis. Different ce...
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations with variable m...
Metastatic disease is themain cause of cancer-relatedmortality due to almost universal therapeutic r...
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations with variable m...
Breast cancer is one of the most frequent malignancies in women worldwide. According to 50-gene sign...
A major component of cancer’s complexity lies in its heterogeneity. Because cancer heterogeneity can...
Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomar...
Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such, heterogenei...
Background and Aims: Characterisation of molecular and cellular heterogeneity in breast cancer (BC) ...
Background and Aims: Characterisation of molecular and cellular heterogeneity in breast cancer (BC) ...
Because every cancer is different, different cancer patients can benefit from different treatments. ...
Because every cancer is different, different cancer patients can benefit from different treatments. ...
Breast cancer is a very heterogeneous disease. This heterogeneity can be observed at many levels, in...
Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic...
Background The intra-tumor diversity of cancer cells is under intense investigation; however, little...
The tumor microenvironment is pivotal in influencing cancer progression and metastasis. Different ce...
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations with variable m...
Metastatic disease is themain cause of cancer-relatedmortality due to almost universal therapeutic r...
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations with variable m...
Breast cancer is one of the most frequent malignancies in women worldwide. According to 50-gene sign...
A major component of cancer’s complexity lies in its heterogeneity. Because cancer heterogeneity can...
Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomar...
Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such, heterogenei...
Background and Aims: Characterisation of molecular and cellular heterogeneity in breast cancer (BC) ...
Background and Aims: Characterisation of molecular and cellular heterogeneity in breast cancer (BC) ...
Because every cancer is different, different cancer patients can benefit from different treatments. ...
Because every cancer is different, different cancer patients can benefit from different treatments. ...
Breast cancer is a very heterogeneous disease. This heterogeneity can be observed at many levels, in...
Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic...