Add to ORKGAccumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological struct...
DNA damage is a major threat to genome stability, as it is estimated that a single cell may incur as...
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of...
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenera...
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenera...
DNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens ...
DNA double-strand breaks (DSBs) jeopardize genome integrity and can—when repaired unfaithfully...
Abstract DNA double-strand breaks are among the most serious types of DNA damage and t...
The most frequent damage on a cell is the DNA double-strand break (DSB). This is sensed and repaired...
Direct cellular DNA damage may lead to genome de-stabilization in unexposed, bystander, cells sharin...
DNA, the central store of our genetic information, constantly incurs damage from agents generated wi...
Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Am...
Of the many types of DNA damage, DNA double-strand breaks (DSBs) are probably the most deleterious. ...
Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging facto...
DNA lesions pose a physical obstacle to DNA-dependent cellular transactions such as replication and ...
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological struct...
DNA damage is a major threat to genome stability, as it is estimated that a single cell may incur as...
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of...
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenera...
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenera...
DNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens ...
DNA double-strand breaks (DSBs) jeopardize genome integrity and can—when repaired unfaithfully...
Abstract DNA double-strand breaks are among the most serious types of DNA damage and t...
The most frequent damage on a cell is the DNA double-strand break (DSB). This is sensed and repaired...
Direct cellular DNA damage may lead to genome de-stabilization in unexposed, bystander, cells sharin...
DNA, the central store of our genetic information, constantly incurs damage from agents generated wi...
Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Am...
Of the many types of DNA damage, DNA double-strand breaks (DSBs) are probably the most deleterious. ...
Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging facto...
DNA lesions pose a physical obstacle to DNA-dependent cellular transactions such as replication and ...
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological struct...
DNA damage is a major threat to genome stability, as it is estimated that a single cell may incur as...
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of...