Add to ORKGModerate to severe diarrhea caused by Shigella is a global health concern due to its substantial contribution to morbidity and mortality in children aged <5 years in low- and middle-income countries. Although antibiotic treatment can be effective, emerging antimicrobial resistance, limited access, and cost affirm the role of vaccines as the most attractive countermeasure. Controlled human infection models (CHIMs) represent a valuable tool for assessing vaccine efficacy and potentially accelerating licensure. Currently, immunological analysis during CHIM studies is customized based on vaccine type, regimen, and administration route. Additionally, differences in type of immunoassays and procedures used limit comparisons across studies. In Nov...
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for...
Background: Shigella is a leading cause of childhood diarrhea and target for vaccine development. Mi...
Abstract: Background: Shigella is a major diarrheal pathogen for which there is presently no vaccine...
Shigella causes morbidity and mortality worldwide, primarily affecting young children living in low-...
In recent years, controlled human infection models (CHIMs) have become available for a range of infe...
Controlled Human Infection Models (CHIMs) now exist for several infectious diseases. CHIMs offer sig...
AbstractShigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013, Shige...
Shigella, a major diarrheal disease pathogen worldwide, is the target of vaccine development. The Gl...
ABSTRACT Controlled human infection models (CHIMs) are useful for vaccine development. To improve on...
ABSTRACT Shigella is an important cause of diarrhea worldwide, with serotypes Shigella flexneri 2a, ...
Vaccine candidates for Shigella are approaching phase 3 clinical trials in the target population of ...
Shigellosis is a mild-to-severe diarrheal infection, caused by the genus Shigella, and is responsibl...
Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve underst...
We refine and clinically parameterize a mathematical model of the humoral immune response against Sh...
Background: Shigellosis accounts for substantial morbidity and mortality worldwide and is the second...
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for...
Background: Shigella is a leading cause of childhood diarrhea and target for vaccine development. Mi...
Abstract: Background: Shigella is a major diarrheal pathogen for which there is presently no vaccine...
Shigella causes morbidity and mortality worldwide, primarily affecting young children living in low-...
In recent years, controlled human infection models (CHIMs) have become available for a range of infe...
Controlled Human Infection Models (CHIMs) now exist for several infectious diseases. CHIMs offer sig...
AbstractShigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013, Shige...
Shigella, a major diarrheal disease pathogen worldwide, is the target of vaccine development. The Gl...
ABSTRACT Controlled human infection models (CHIMs) are useful for vaccine development. To improve on...
ABSTRACT Shigella is an important cause of diarrhea worldwide, with serotypes Shigella flexneri 2a, ...
Vaccine candidates for Shigella are approaching phase 3 clinical trials in the target population of ...
Shigellosis is a mild-to-severe diarrheal infection, caused by the genus Shigella, and is responsibl...
Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve underst...
We refine and clinically parameterize a mathematical model of the humoral immune response against Sh...
Background: Shigellosis accounts for substantial morbidity and mortality worldwide and is the second...
Shigellosis is a mild-to-severe diarrheal infection caused by the genus Shigella and responsible for...
Background: Shigella is a leading cause of childhood diarrhea and target for vaccine development. Mi...
Abstract: Background: Shigella is a major diarrheal pathogen for which there is presently no vaccine...