AMP-activated protein kinase (AMPK) is an evolutionarily highly-conserved serine/threonine kinase that acts as a cellular energy sensor and integrator of metabolic signals at both the cellular and whole-body level. Interest in its cardiac role stemmed from the discovery that dominant mutations in the gene encoding its regulatory γ subunit (PRKAG2) were the cause of a cardiomyopathy characterised by left ventricular hypertrophy (LVH), ventricular pre-excitation, myocardial glycogen storage and progressive cardiac conduction disease. Several cardiac-restricted overexpressing transgenic (TG) murine models have been described which recapitulate much of this, but at the expense of markedly altered γ-isoform stoichiometry and use of an unphysiolo...
AMP-activated protein kinase (AMPK), the key sensor and regulator of cellular energy status, is a he...
AMP-activated protein kinase (AMPK) is widely regarded as a master regulator of energy homeostasis, ...
PRKAG2 encodes the γ2-subunit isoform of the 5' AMP-activated protein kinase (AMPK), a heterotrimeri...
Characterized by excessive myocardial glycogen deposition, cardiac hypertrophy, frequent cardiac arr...
Rationale: AMP-activated protein kinase is a master regulator of cell metabolism and an attractive d...
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that pla...
AbstractHuman mutations in PRKAG2, the gene encoding the γ2 subunit of AMP activated protein kinase ...
AMP-activated protein kinase ( AMPK) is the downstream component of a protein kinase cascade that pl...
AMP-activated protein kinase (AMPK) is a metabolic enzyme that can be activated by nutrient stress o...
AMP-activated protein kinase (AMPK) is a metabolic enzyme that can be activated by nutrient stress o...
Familial hypertrophic cardiomyopathy (HCM) is most commonly caused by mutations in sarcomeric protei...
AbstractBackgroundPRKAG2 gene encodes the γ2 regulatory subunit of AMP-activated protein kinase (AMP...
Abstract Background The cardiac PRKAG2 mutation in th...
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eu...
Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopath...
AMP-activated protein kinase (AMPK), the key sensor and regulator of cellular energy status, is a he...
AMP-activated protein kinase (AMPK) is widely regarded as a master regulator of energy homeostasis, ...
PRKAG2 encodes the γ2-subunit isoform of the 5' AMP-activated protein kinase (AMPK), a heterotrimeri...
Characterized by excessive myocardial glycogen deposition, cardiac hypertrophy, frequent cardiac arr...
Rationale: AMP-activated protein kinase is a master regulator of cell metabolism and an attractive d...
AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that pla...
AbstractHuman mutations in PRKAG2, the gene encoding the γ2 subunit of AMP activated protein kinase ...
AMP-activated protein kinase ( AMPK) is the downstream component of a protein kinase cascade that pl...
AMP-activated protein kinase (AMPK) is a metabolic enzyme that can be activated by nutrient stress o...
AMP-activated protein kinase (AMPK) is a metabolic enzyme that can be activated by nutrient stress o...
Familial hypertrophic cardiomyopathy (HCM) is most commonly caused by mutations in sarcomeric protei...
AbstractBackgroundPRKAG2 gene encodes the γ2 regulatory subunit of AMP-activated protein kinase (AMP...
Abstract Background The cardiac PRKAG2 mutation in th...
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eu...
Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopath...
AMP-activated protein kinase (AMPK), the key sensor and regulator of cellular energy status, is a he...
AMP-activated protein kinase (AMPK) is widely regarded as a master regulator of energy homeostasis, ...
PRKAG2 encodes the γ2-subunit isoform of the 5' AMP-activated protein kinase (AMPK), a heterotrimeri...