Add to ORKGA study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans-decalin ring of the natural product. The tetronic acid moiety of the molecule was prepared by a Dieckmann cyclization. The cyclization of the tetronic acid to the trans-decalin double bond to form a seven-membered ring was examined
This thesis is concerned with the synthesis of small molecules that mimic tetramate- and pyrrolidin...
Antibiotics are one of the most important groups of drugs ever discovered. In addition to their clin...
Tetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics...
A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction...
Tetrodecamycin (1) is a novel α-(γ-hydroxyacyl) tetronic acid based polyketide antibiotic isolated f...
This thesis explores the development of the tandem oxy-Cope/ene rearrangement and its application to...
Many natural products contain a tetramic acid (pyrrolidine-2,4-dione) ring system as an integral par...
The formation of rings in carbon backbones is essential for the biological activity of many natural ...
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citr...
Research toward the total synthesis of the promising antibiotic lactonamycin is reported. Lactonamyc...
During the last decades the interest towards natural products containing the tetronic acid moiety au...
AbstractThe tetrodecamycins are a group of secondary metabolites that are characterized by the prese...
The intramolecular Diels-Alder reaction is widely recognized as a powerful and versatile method for ...
Decalin-containing natural products along with tetramic acid moieties present characteristic functio...
In part I of this thesis are described some studies toward the total synthesis of tetracycline. Att...
This thesis is concerned with the synthesis of small molecules that mimic tetramate- and pyrrolidin...
Antibiotics are one of the most important groups of drugs ever discovered. In addition to their clin...
Tetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics...
A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction...
Tetrodecamycin (1) is a novel α-(γ-hydroxyacyl) tetronic acid based polyketide antibiotic isolated f...
This thesis explores the development of the tandem oxy-Cope/ene rearrangement and its application to...
Many natural products contain a tetramic acid (pyrrolidine-2,4-dione) ring system as an integral par...
The formation of rings in carbon backbones is essential for the biological activity of many natural ...
The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citr...
Research toward the total synthesis of the promising antibiotic lactonamycin is reported. Lactonamyc...
During the last decades the interest towards natural products containing the tetronic acid moiety au...
AbstractThe tetrodecamycins are a group of secondary metabolites that are characterized by the prese...
The intramolecular Diels-Alder reaction is widely recognized as a powerful and versatile method for ...
Decalin-containing natural products along with tetramic acid moieties present characteristic functio...
In part I of this thesis are described some studies toward the total synthesis of tetracycline. Att...
This thesis is concerned with the synthesis of small molecules that mimic tetramate- and pyrrolidin...
Antibiotics are one of the most important groups of drugs ever discovered. In addition to their clin...
Tetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics...