Add to ORKGThe requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered druggable molecular pathways. We identified a selective inhibitor of the Plasmodium falciparum protein kinase PfCLK3, which we used in combination with chemogenetics to validate PfCLK3 as a drug target acting at multiple parasite life stages. Consistent with a role for PfCLK3 in RNA splicing, inhibition resulted in the down-regulation of more than 400 essential parasite genes. Inhibition of PfCLK3 mediated rapid killing of asexual liver- and blood-stage P. falciparum and blockade of gametocyte development, thereby preventing transmission, and also showed parasiticidal activity against P. ...
Although current malaria therapies inhibit pathways encoded in the parasite's genome, we have looked...
To combat drug resistance, new chemical entities are urgently required for use in next generation an...
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate ...
The requirement for next-generation antimalarials to be both curative and transmission-blocking nece...
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing ...
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing ...
Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in r...
Plasmodium falciparum, the primary causative agent of malaria in humans, is responsible for life-thr...
Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cance...
Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and m...
Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. Th...
To combat drug resistance, new chemical entities are urgently required for use in next generation an...
<div><p>Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosph...
© 2020 The Authors The search for antimalarial chemotypes with modes of action unrelated to existing...
Protein and phosphoinositide kinases have been successfully exploited as drug targets in various dis...
Although current malaria therapies inhibit pathways encoded in the parasite's genome, we have looked...
To combat drug resistance, new chemical entities are urgently required for use in next generation an...
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate ...
The requirement for next-generation antimalarials to be both curative and transmission-blocking nece...
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing ...
The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing ...
Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in r...
Plasmodium falciparum, the primary causative agent of malaria in humans, is responsible for life-thr...
Protein kinases (PKs) are prime targets for drug discovery in a variety of diseases, including cance...
Malaria still remains one of the deadliest infectious diseases, and has a tremendous morbidity and m...
Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. Th...
To combat drug resistance, new chemical entities are urgently required for use in next generation an...
<div><p>Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosph...
© 2020 The Authors The search for antimalarial chemotypes with modes of action unrelated to existing...
Protein and phosphoinositide kinases have been successfully exploited as drug targets in various dis...
Although current malaria therapies inhibit pathways encoded in the parasite's genome, we have looked...
To combat drug resistance, new chemical entities are urgently required for use in next generation an...
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate ...