Add to ORKGTitin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies
Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of...
BACKGROUND: Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilat...
Dilated cardiomyopathy (DCM) is an etiologically heterogeneous cardiac disease characterized by left...
5siDilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart ...
Titin (TTN) is known as the largest sarcomeric protein that resides within the heart muscle. Due to ...
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyop...
Background—High throughput next generation sequencing techniques have made whole genome sequencing a...
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abunda...
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abunda...
Background — High throughput next-generation sequencing techniques have made whole genome sequencing...
5siPurpose of Review The giant protein titin forms the “elastic” filament of the sarcomere, essentia...
BACKGROUND-\u2014The titin gene (TTN) encodes the largest human protein, which plays a central role ...
BackgroundTruncating mutations in the giant sarcomeric gene Titin are the most common type of geneti...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of...
BACKGROUND: Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilat...
Dilated cardiomyopathy (DCM) is an etiologically heterogeneous cardiac disease characterized by left...
5siDilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart ...
Titin (TTN) is known as the largest sarcomeric protein that resides within the heart muscle. Due to ...
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyop...
Background—High throughput next generation sequencing techniques have made whole genome sequencing a...
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abunda...
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abunda...
Background — High throughput next-generation sequencing techniques have made whole genome sequencing...
5siPurpose of Review The giant protein titin forms the “elastic” filament of the sarcomere, essentia...
BACKGROUND-\u2014The titin gene (TTN) encodes the largest human protein, which plays a central role ...
BackgroundTruncating mutations in the giant sarcomeric gene Titin are the most common type of geneti...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of...
BACKGROUND: Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilat...
Dilated cardiomyopathy (DCM) is an etiologically heterogeneous cardiac disease characterized by left...