Colony stimulating factor-1 (CSF-1) regulates macrophage morphology and motility, as well as mononuclear phagocytic cell proliferation and differentiation. The CSF-1 receptor (CSF-1R) transduces these pleiotropic signals through autophosphorylation of eight intracellular tyrosine residues. We have used a novel bone-marrow-derived macrophage cell line system to examine specific signaling pathways activated by tyrosine-phosphorylated CSF-1R in macrophages. Screening of macrophages expressing a single species of CSF-1R with individual tyrosine-to-phenylalanine residue mutations revealed striking morphological alterations upon mutation of Y721. M−/−.Y721F cells were apolar and ruffled poorly in response to CSF-1. Y721-P-mediated CSF-1R signalin...
Macrophages are white blood cells involved in many aspects of host defence, immunity, pathology and ...
We previously reported that bacterial products such as LPS and CpG DNA down-modulated cell surface l...
Prostate cancer is a major public health concern and one of the most prevalent forms of cancer world...
Macrophages interact with cells in every organ to facilitate tissue development, function and repair...
Published: 18 June 2017Macrophages interact with cells in every organ to facilitate tissue developme...
Abstract: CSF-1 is the major regulator of tissue macrophage development and function. A GM-CSF-depen...
CSF-1 regulates macrophage differentiation, survival, and function, and is an attractive therapeutic...
Macrophage colony-stimulating factor (CSF-1) binds to a receptor (CSF-1R) encoded by the c-fms proto...
Phosphoinositide 3-kinases (PI3Ks) are important regulators of cell migration. The PI3K isoform γ is...
M1 myeloid cells transfected with the wild-type (WT) colony-stimulating factor-1 (CSF-1) receptor (C...
Macrophage colony stimulating factor receptor (MCSFR a.k.a CSF-1R), is a receptor tyrosine kinase (R...
[[abstract]]Purpose: Targeting tumor-associated macrophages with CSF-1R inhibition reveals a strateg...
M-CSF is known to induce cytoskeletal reorganization in macrophages and osteoclasts by activation of...
CSF1 is the primary growth factor controlling macrophage numbers, but whether expression of the CSF1...
Macrophage colony stimulating factor (M-CSF or CSF-1) acts to regulate the development and function ...
Macrophages are white blood cells involved in many aspects of host defence, immunity, pathology and ...
We previously reported that bacterial products such as LPS and CpG DNA down-modulated cell surface l...
Prostate cancer is a major public health concern and one of the most prevalent forms of cancer world...
Macrophages interact with cells in every organ to facilitate tissue development, function and repair...
Published: 18 June 2017Macrophages interact with cells in every organ to facilitate tissue developme...
Abstract: CSF-1 is the major regulator of tissue macrophage development and function. A GM-CSF-depen...
CSF-1 regulates macrophage differentiation, survival, and function, and is an attractive therapeutic...
Macrophage colony-stimulating factor (CSF-1) binds to a receptor (CSF-1R) encoded by the c-fms proto...
Phosphoinositide 3-kinases (PI3Ks) are important regulators of cell migration. The PI3K isoform γ is...
M1 myeloid cells transfected with the wild-type (WT) colony-stimulating factor-1 (CSF-1) receptor (C...
Macrophage colony stimulating factor receptor (MCSFR a.k.a CSF-1R), is a receptor tyrosine kinase (R...
[[abstract]]Purpose: Targeting tumor-associated macrophages with CSF-1R inhibition reveals a strateg...
M-CSF is known to induce cytoskeletal reorganization in macrophages and osteoclasts by activation of...
CSF1 is the primary growth factor controlling macrophage numbers, but whether expression of the CSF1...
Macrophage colony stimulating factor (M-CSF or CSF-1) acts to regulate the development and function ...
Macrophages are white blood cells involved in many aspects of host defence, immunity, pathology and ...
We previously reported that bacterial products such as LPS and CpG DNA down-modulated cell surface l...
Prostate cancer is a major public health concern and one of the most prevalent forms of cancer world...