Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measurements are essential to understanding the role of biomechanics in cell regulation and function. Traction force microscopy remains the most broadly applied force probing technology but typically restricts itself to single-plane two-dimensional quantifications with limited spatiotemporal resolution. Here, we introduce an enhanced force measurement technique combining 3D super-resolution fluorescence structural illumination microscopy and traction force microscopy (3D-SIM-TFM) offering increased spatiotemporal resolution, opening-up unprecedented insights into physiological three-dimensional force production in living cells
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...
<div><p>Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interac...
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measur...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measur...
Quantifying cell generated mechanical forces is key to furthering our understanding of mechanobiolog...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measu...
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understan...
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understan...
Quantifying small, rapidly progressing three-dimensional forces generated by cells remains a major c...
Animal cells continuously sense and respond to mechanical force. Quantifying these forces remains a ...
Animal cells continuously sense and respond to mechanical force. Quantifying these forces remains a ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...
<div><p>Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interac...
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measur...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measur...
Quantifying cell generated mechanical forces is key to furthering our understanding of mechanobiolog...
Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measu...
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understan...
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understan...
Quantifying small, rapidly progressing three-dimensional forces generated by cells remains a major c...
Animal cells continuously sense and respond to mechanical force. Quantifying these forces remains a ...
Animal cells continuously sense and respond to mechanical force. Quantifying these forces remains a ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution ...
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...
<div><p>Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interac...
Traction Force Microscopy (TFM) is a powerful approach for quantifying cell-material interactions th...