The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation through the pores and also of the DNA conformation. Our studies show that ssDNA translocates through hourglass-shaped pores with hydrophobic constriction regions when an electric field is applied. The constriction provides a barrier to translocation and thereby slows down DNA movement through the pore compared with pores without the constriction. We show that ssDNA moves through these hydrophobic pores in an extended conformation and therefore does not form undesirable secondary structures that may affect the accuracy of partial current blockages for DNA sequencing
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
DNA sequencing is of great significance to molecular biology with myriad applications in fields such...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
AbstractWe have previously demonstrated that a nanometer-diameter pore in a nanometer-thick metal-ox...
AbstractNanoscale pores have proved useful as a means to assay DNA and are actively being developed ...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
AbstractWe have explored the electromechanical properties of DNA on a nanometer-length scale using a...
AbstractThis article explores the role of some geometrical factors on the electrophoretically driven...
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation ...
DNA sequencing is of great significance to molecular biology with myriad applications in fields such...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
AbstractWe have previously demonstrated that a nanometer-diameter pore in a nanometer-thick metal-ox...
AbstractNanoscale pores have proved useful as a means to assay DNA and are actively being developed ...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
Many important processes in biology involve the translocation of a biopolymer through a nanometer-sc...
AbstractWe have explored the electromechanical properties of DNA on a nanometer-length scale using a...
AbstractThis article explores the role of some geometrical factors on the electrophoretically driven...
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...
International audienceThis article explores the role of some geometrical factors on the electrophore...