DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-mole...
ABSTRACT: Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly im...
Aptamers are a class of nucleic acid molecules that mimic antibodies by folding, in a sequence speci...
We describe an innovative selection approach to generate self-reporting aptamers (SRAs) capable of c...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
The screening of encoded self-assembling chemical libraries allows the identification of fragment pa...
Molecular recognition of disease biomarkers is essential for the detection, monitoring, and treatmen...
Biological reagents that recognize target molecules with high affinity and specificity are widely us...
DNA-encoded libraries are becoming increasingly used to identify chemical probes and hit molecules o...
Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the ...
Competition-enhanced ligand screening (CompELS) was employed to rapidly screen through large DNA lib...
A challenge for the use of aptamers as biosensors is how to signal the occurrence of their ligand bi...
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamer...
The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-asse...
ii Human serum albumin (HSA) is a highly abundant protein in the human plasma, causing the discovery...
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-mole...
ABSTRACT: Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly im...
Aptamers are a class of nucleic acid molecules that mimic antibodies by folding, in a sequence speci...
We describe an innovative selection approach to generate self-reporting aptamers (SRAs) capable of c...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
The screening of encoded self-assembling chemical libraries allows the identification of fragment pa...
Molecular recognition of disease biomarkers is essential for the detection, monitoring, and treatmen...
Biological reagents that recognize target molecules with high affinity and specificity are widely us...
DNA-encoded libraries are becoming increasingly used to identify chemical probes and hit molecules o...
Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the ...
Competition-enhanced ligand screening (CompELS) was employed to rapidly screen through large DNA lib...
A challenge for the use of aptamers as biosensors is how to signal the occurrence of their ligand bi...
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamer...
The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-asse...
ii Human serum albumin (HSA) is a highly abundant protein in the human plasma, causing the discovery...
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-mole...
ABSTRACT: Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly im...
Aptamers are a class of nucleic acid molecules that mimic antibodies by folding, in a sequence speci...