Variability in Golimumab Exposure: A 'Real-Life' Observational Study in Active Ulcerative Colitis
- Detrez, Iris
- Dreesen, Erwin
- Van Stappen, Thomas
- de Vries, Annick
- Brouwers, Els
- Van Assche, Gert
- Vermeire, Séverine
- Ferrante, Marc
- Gils, Ann
Publication date
May 2016
DOI Publisher
Elsevier Science BV ISSN
1873-9946 Journal
issn:1873-9946 Citation count (estimate)
24Abstract
Golimumab has been approved recently to treat refractory moderate-to-severe ulcerative colitis [UC]. To date it is not clear why a considerable fraction of patients do not respond, or lose initial response, to golimumab therapy. Our aim was to investigate whether a low golimumab serum concentration and/or a positive anti-golimumab antibody status reduces the efficacy of this drug in patients with UC.status: publishe
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