Add to ORKG(-)-Pseudodistomin E has been prepared for the first time, allowing its structure and absolute configuration to be confirmed. The established conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,5-dienoate generated the C(2)-stereocenter, and iodolactonisation of a derivative generated the remaining two stereogenic centers. Ensuing iodide displacement was achieved using a tethering strategy, to introduce the nitrogen atom to C(5). Decarboxylative coupling of a carboxylic acid with a dialkylzinc reagent completed construction of the tridecadienyl chain
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...
A strategy for the asymmetric synthesis of a homochiral differentially protected pseudo-meso bis-β-a...
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...
Conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,...
Conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,...
This thesis centres on asymmetric syntheses of the pseudodistomin alkaloids, initially targeting a m...
This thesis centres on asymmetric syntheses of the pseudodistomin alkaloids, initially targeting a m...
This thesis describes investigations into the total asymmetric synthesis of alkaloids from polysubst...
The product distribution upon conjugate addition of homochiral lithium N-benzyl-N-α-methylbenzylamid...
Double asymmetric induction as a mechanistic probe indicates that, for the conjugate addition of (R)...
Double asymmetric induction as a mechanistic probe indicates that, for the conjugate addition of (R)...
Diastereoselective conjugate addition of homochiral lithium (R)-N-allyl-N-α-methylbenzylamide to met...
Diastereoselective conjugate addition of homochiral lithium (R)-N-allyl-N-alpha-methylbenzylamide to...
The highly diastereoselective asymmetric conjugate addition of lithium (-4-A'-benzyl-a-methylbenzyla...
As part of a long-term goal directed towards the ab initio asymmetric synthesis of unnatural amino s...
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...
A strategy for the asymmetric synthesis of a homochiral differentially protected pseudo-meso bis-β-a...
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...
Conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,...
Conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,...
This thesis centres on asymmetric syntheses of the pseudodistomin alkaloids, initially targeting a m...
This thesis centres on asymmetric syntheses of the pseudodistomin alkaloids, initially targeting a m...
This thesis describes investigations into the total asymmetric synthesis of alkaloids from polysubst...
The product distribution upon conjugate addition of homochiral lithium N-benzyl-N-α-methylbenzylamid...
Double asymmetric induction as a mechanistic probe indicates that, for the conjugate addition of (R)...
Double asymmetric induction as a mechanistic probe indicates that, for the conjugate addition of (R)...
Diastereoselective conjugate addition of homochiral lithium (R)-N-allyl-N-α-methylbenzylamide to met...
Diastereoselective conjugate addition of homochiral lithium (R)-N-allyl-N-alpha-methylbenzylamide to...
The highly diastereoselective asymmetric conjugate addition of lithium (-4-A'-benzyl-a-methylbenzyla...
As part of a long-term goal directed towards the ab initio asymmetric synthesis of unnatural amino s...
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...
A strategy for the asymmetric synthesis of a homochiral differentially protected pseudo-meso bis-β-a...
Stereoselective synthesis of some pseudopeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedio...