Add to ORKGA description of the materials and methods is included within the TEP datasheet. Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 knockdown or LIMK1 inhibition. Here we present a target enabling package for the therapeutic target LIMK1. We include crystal structures of BMPR2, LIMK1, LIMK2 and the LIMK1-cofilin complex, as well as multiple assays for small molecule inhibitor screen...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
A description of the materials and methods is included within the TEP datasheet. Loss of the transla...
A description of the materials and methods is included within the TEP datasheet. Loss of the transla...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
A description of the materials and methods is included within the TEP datasheet. Loss of the transla...
A description of the materials and methods is included within the TEP datasheet. Loss of the transla...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
<p>Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...
Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BM...