With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic risk factors for late-onset Alzheimer's disease, despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a cancer-associated variant of the cell cycle inhibitor gene p21cip1 is associated with increased risk of Alzheimer's disease. The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the p21cip1 variant with Alzheime...
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofib...
Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly peo...
More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but reported ...
With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic ...
<div><p>With the exception of ApoE4, genome-wide association studies have failed to identify strong ...
With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic ...
Background: Variation at the cyclin-dependent kinase inhibitor gene P21 in a patient sample of the I...
Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genet...
Linkage studies have suggested a susceptibility locus for late-onset Alzheimer’s disease (LOAD) on c...
AbstractGenetic susceptibility, is considered to be involved in neurodegenerative diseases such as A...
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide associatio...
This is an open access article distributed under the Creative Commons Attribution License, which pe...
The contribution of genetic variation to the risk for late-onset Alzheimer’s disease is well-accepte...
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD...
About 35 million people worldwide were suffered from Alzheimer’s disease (AD) in 2014 and the number...
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofib...
Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly peo...
More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but reported ...
With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic ...
<div><p>With the exception of ApoE4, genome-wide association studies have failed to identify strong ...
With the exception of ApoE4, genome-wide association studies have failed to identify strong genetic ...
Background: Variation at the cyclin-dependent kinase inhibitor gene P21 in a patient sample of the I...
Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genet...
Linkage studies have suggested a susceptibility locus for late-onset Alzheimer’s disease (LOAD) on c...
AbstractGenetic susceptibility, is considered to be involved in neurodegenerative diseases such as A...
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide associatio...
This is an open access article distributed under the Creative Commons Attribution License, which pe...
The contribution of genetic variation to the risk for late-onset Alzheimer’s disease is well-accepte...
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD...
About 35 million people worldwide were suffered from Alzheimer’s disease (AD) in 2014 and the number...
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofib...
Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly peo...
More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but reported ...