Add to ORKGPrimary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, w...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...
Published by Oxford University Press. All rights reserved.Primary open-angle glaucoma (POAG), the mo...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for whic...
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the g...
Abstract Background Genome-wide association studies (GWAS) have identified association of common all...
Abstract Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex dise...
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...
Published by Oxford University Press. All rights reserved.Primary open-angle glaucoma (POAG), the mo...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for whic...
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the g...
Abstract Background Genome-wide association studies (GWAS) have identified association of common all...
Abstract Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex dise...
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify...
Published by Oxford University Press. All rights reserved.Primary open-angle glaucoma (POAG), the mo...