Add to ORKGHormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer
The goal of this project was to understand the mechanisms by which hypoxia contributes to breast can...
Triple-negative breast cancer (TNBC) surpasses other BC subtypes as the most challenging to treat du...
Hypoxia is a hallmark of solid tumors that drives malignant progression by altering epigenetic contr...
Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor...
Estrogen receptor alpha (ERalpha) plays an important role in breast cancer. Upregulation of HIF-1alp...
Hormones and growth factors (GFs) are signaling molecules implicated in the regulation of a variety ...
International audienceEstrogen receptor-alpha (ER alpha) is the driving transcription factor in 70% ...
A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous stud...
Tumors are complex tissues in which transformed cells communicate with the surrounding microenvironm...
Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, ho...
The involvement of estrogen (E2) and hypoxia in tumor progression is well established. Hypoxia has b...
Tumors are complex tissues in which transformed cells communicate with the surrounding microenviron...
Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissem...
Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamo...
Hypoxia is an inherent condition of tumors and contributes to cancer development and progression. Hy...
The goal of this project was to understand the mechanisms by which hypoxia contributes to breast can...
Triple-negative breast cancer (TNBC) surpasses other BC subtypes as the most challenging to treat du...
Hypoxia is a hallmark of solid tumors that drives malignant progression by altering epigenetic contr...
Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor...
Estrogen receptor alpha (ERalpha) plays an important role in breast cancer. Upregulation of HIF-1alp...
Hormones and growth factors (GFs) are signaling molecules implicated in the regulation of a variety ...
International audienceEstrogen receptor-alpha (ER alpha) is the driving transcription factor in 70% ...
A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous stud...
Tumors are complex tissues in which transformed cells communicate with the surrounding microenvironm...
Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, ho...
The involvement of estrogen (E2) and hypoxia in tumor progression is well established. Hypoxia has b...
Tumors are complex tissues in which transformed cells communicate with the surrounding microenviron...
Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissem...
Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamo...
Hypoxia is an inherent condition of tumors and contributes to cancer development and progression. Hy...
The goal of this project was to understand the mechanisms by which hypoxia contributes to breast can...
Triple-negative breast cancer (TNBC) surpasses other BC subtypes as the most challenging to treat du...
Hypoxia is a hallmark of solid tumors that drives malignant progression by altering epigenetic contr...