Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells. To overcome this, many different drug delivery systems have been devised. Among others, short delivery peptides, called cell-penetrating peptides (CPPs), have been demonstrated to allow for efficient delivery of nucleic acids and their ON analogs, in both cell culture and animal models. In this review, we provide brief overview of the latest advances in nucleic acid delivery with CPPs, covering the two main vectorization strate...
Nanomedicine has opened the way to the design of more efficient diagnostics and therapeutics. Moreov...
Cellular and nuclear delivery of biomolecules is limited by low membrane permeability. Cell-penetrat...
Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse...
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back...
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back...
The hydrophobic nature of cell membranes is one of the major obstacles in the therapeutic delivery o...
Many viral and nonviral systems have been developed to aid delivery of biologically active molecules...
The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules includ...
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocatin...
Establishment of multiple novel mechanisms and applications of cell-penetrating peptides (CPP) has b...
International audienceGene therapy offers the possibility to skip, repair, or silence faulty genes o...
International audienceThe recent discovery of new potent therapeutic molecules that do not reach the...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion, improving the ...
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by...
Nanomedicine has opened the way to the design of more efficient diagnostics and therapeutics. Moreov...
Cellular and nuclear delivery of biomolecules is limited by low membrane permeability. Cell-penetrat...
Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse...
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back...
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back...
The hydrophobic nature of cell membranes is one of the major obstacles in the therapeutic delivery o...
Many viral and nonviral systems have been developed to aid delivery of biologically active molecules...
The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules includ...
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocatin...
Establishment of multiple novel mechanisms and applications of cell-penetrating peptides (CPP) has b...
International audienceGene therapy offers the possibility to skip, repair, or silence faulty genes o...
International audienceThe recent discovery of new potent therapeutic molecules that do not reach the...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion, improving the ...
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by...
Nanomedicine has opened the way to the design of more efficient diagnostics and therapeutics. Moreov...
Cellular and nuclear delivery of biomolecules is limited by low membrane permeability. Cell-penetrat...
Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse...