DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature
- Wauters, Els
- Janssens, Wim
- Vansteenkiste, Johan
- Decaluwé, Herbert
- Heulens, Nele
- Thienpont, Bernard
- Zhao, Hui
- Smeets, Dominiek
- Sagaert, Xavier
- Coolen, Johan
- Decramer, Marc
- Liston, Adrian
- De Leyn, Paul
- Moisse, Matthieu
- Lambrechts, Diether
Publication date
December 2015
DOI Publisher
British Medical Association ISSN
0040-6376 Journal
0040-6376 Citation count (estimate)
15Abstract
Non-small cell lung cancer (NSCLC) is a heterogeneous disorder consisting of distinct molecular subtypes each characterised by specific genetic and epigenetic profiles. Here, we aimed to identify novel NSCLC subtypes based on genome-wide methylation data, assess their relationship with smoking behaviour, age, COPD, emphysema and tumour histopathology, and identify the molecular pathways underlying each subtype.status: publishe
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