Add to ORKGIt is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and exp...
Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models sho...
In many countries, animal experiments can only be performed when their necessity has been demonstrat...
Animals are still widely used in drug development and safety tests, despite evidence for their lack ...
Abstract It is one of the central aims of the philosophy of science to elucidate the meanings of sci...
Every year, and in countries around the world, significant time and resources are devoted to the nob...
Models have been a tool of science at least since the 18th century and serve a variety of purposes f...
The development of efficient ways to predict, prevent, diagnose and treat human diseases is of great...
Over the past several decades, various animal models have been used extensively to characterize the ...
The key assumptions underlying modern toxicology are that (1) animals can serve as accurate predicti...
The assumption that animal models are reasonably predictive of human outcomes provides the basis for...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Mice off...
Motivation: Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormo...
Recently, several articles have been pub-lished questioning the usefulness of animal experiments for...
Widespread reliance on animal models during preclinical research and toxicity testing assumes their ...
Animal use continues to be central to preclinical drug development, in spite of a lack of its demons...
Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models sho...
In many countries, animal experiments can only be performed when their necessity has been demonstrat...
Animals are still widely used in drug development and safety tests, despite evidence for their lack ...
Abstract It is one of the central aims of the philosophy of science to elucidate the meanings of sci...
Every year, and in countries around the world, significant time and resources are devoted to the nob...
Models have been a tool of science at least since the 18th century and serve a variety of purposes f...
The development of efficient ways to predict, prevent, diagnose and treat human diseases is of great...
Over the past several decades, various animal models have been used extensively to characterize the ...
The key assumptions underlying modern toxicology are that (1) animals can serve as accurate predicti...
The assumption that animal models are reasonably predictive of human outcomes provides the basis for...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract Mice off...
Motivation: Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormo...
Recently, several articles have been pub-lished questioning the usefulness of animal experiments for...
Widespread reliance on animal models during preclinical research and toxicity testing assumes their ...
Animal use continues to be central to preclinical drug development, in spite of a lack of its demons...
Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models sho...
In many countries, animal experiments can only be performed when their necessity has been demonstrat...
Animals are still widely used in drug development and safety tests, despite evidence for their lack ...