Presymptomatic Identification of Cancers in Pregnant Women During Noninvasive Prenatal Testing
- Amant, Frédéric
- Verheecke, Magali
- Wlodarska, Iwona
- Dehaspe, Luc
- Brady, Paul
- Brison, Nathalie
- Van Den Bogaert, Kris
- Dierickx, Daan
- Vandecaveye, Vincent
- Tousseyn, Thomas
- Moerman, Philippe
- Vanderstichele, Adriaan
- Vergote, Ignace
- Neven, Patrick
- Berteloot, Patrick
- Putseys, Katrien
- Vandenberghe, Peter
- Vermeesch, Joris
Publication date
September 2015
DOI Publisher
JAMA ISSN
2374-2437 Journal
issn:2374-2437 Citation count (estimate)
53Abstract
Noninvasive prenatal testing (NIPT) for fetal aneuploidy by scanning cell-free fetal DNA in maternal plasma is rapidly becoming a major prenatal genetic test. Similar to placental DNA, tumor DNA can be detected in the plasma, and analysis of cell-free tumor DNA can be used to characterize and monitor cancers. We show that plasma DNA profiling allows for presymptomatic detection of tumors in pregnant women undergoing routine NIPT.status: publishe
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