Train High Eat Low for Osteoarthritis study (THE LO study): protocol for a randomized controlled trial
- Guerrero, Yareni
- Soomro, Najeebullah
- Wilson, Guy
- Dam, Yian
- Meiklejohn, Jacinda
- Simpson, Kylie
- Smith, Richard
- Brand-Miller, Jennie
- Simic, Milena
- O'Connor, Helen
- Mavros, Yorgi
- Foroughi, Nasim
- Poon, Tat
- Bradshaw, Kate
- March, Lyn
- Vanwanseele, Benedicte
- Eckstein, Felix
- Fransen, Marlene
- Bergamasco, Joao
- Anandacoomarasamy, Ananthila
- Singh, Maria Fiatarone
DOIAbstract
Osteoarthritis (OA) is one of the most prevalent chronic conditions among older adults, with the medial tibio-femoral joint being most frequently affected. The knee adduction moment is recognized as a surrogate measure of the medial tibio-femoral compartment joint load and therefore represents a valid intervention target. This article provides the rationale and methodology for THE LO study (Train High, Eat Low for Osteoarthritis), which is a randomized controlled trial that is investigating the effects of a unique, targeted lifestyle intervention in overweight/obese adults with symptomatic medial knee OA.status: publishe
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