Associations of Soluble CD14 and Endotoxin with Mortality, Cardiovascular Disease, and Progression of Kidney Disease among Patients with CKD
- Poesen, Ruben
- Ramezani, Ali
- Claes, Kathleen
- Augustijns, Patrick
- Kuypers, Dirk
- Barrows, Ian R
- Muralidharan, Jagadeesan
- Evenepoel, Pieter
- Meijers, Björn
- Raj, Dominic S
Publication date
September 2015
DOI Publisher
American Society of Nephrology ISSN
1555-9041 Journal
1555-905xAbstract
CD14 plays a key role in the innate immunity as pattern-recognition receptor of endotoxin. Higher levels of soluble CD14 (sCD14) are associated with overall mortality in hemodialysis patients. The influence of kidney function on plasma sCD14 levels and its relationship with adverse outcomes in patients with CKD not yet on dialysis is unknown. This study examines the associations between plasma levels of sCD14 and endotoxin with adverse outcomes in patients with CKD.status: publishe
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