Add to ORKGThe chemical synthesis of some acyclic alpha-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylamide nucleosides (10-12)a-c is described. The treatment of IH-pyrazolo[3,4-d]pyrimidin-4-thione 1 with compounds 2a-c gave, regioselectively, ethyl alpha-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylates 3a-c, respectively. These heterocycles were alkylated, separately, with alkylating agents 4, 5 and 6 to give, regioselectively, the N1-acyclic nucleosides (7-9)a-c which were deprotected to afford the desired products (10-12)a-c. All synthetic compounds were characterized on the basis of their physical and spectroscopic properties. The products (10-12)a-c were evaluated for their inhibitory effects against the replication of HIV-1 (III(B)), HIV-2 (ROD), v...
International audienceThe synthesis of novel acyclic nucleosides in the 5-alkynyl and 6-alkylfuro[2,...
Herein we describe a class of unconventional nucleosides (methyloxynucleosides) that combine unconve...
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R$\sb{\...
The reaction of 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 11 with compounds 12a-c produces ethyl alph...
International audienceThe reaction of 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 11 with compounds 12a...
The chemical synthesis and biological evaluation of some acyclic alpha-[6-(1'-carbamoylalkylthio)-1H...
Some compounds, analogous to those found in naturally occurring systems, are found to possess chemo...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
Several pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one ribonucleosides were prepared and tested fo...
A new series of pyrazole 4–7 and pyrazolo[1,5-a]pyrimidine 8–13 were synthesized by usin...
A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues h...
Pyrazolo[1,5-c]pyrimidines are biologically active, synthetically useful and important heterocyclic ...
Optically pure acyclic nucleoside analogues with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dih...
3(5)-Carboxamido-4-(beta-D-ribofuranosyl)pyrazoles bearing 2-benzamido (15) and 3-mesyloxy (29) isos...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
International audienceThe synthesis of novel acyclic nucleosides in the 5-alkynyl and 6-alkylfuro[2,...
Herein we describe a class of unconventional nucleosides (methyloxynucleosides) that combine unconve...
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R$\sb{\...
The reaction of 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 11 with compounds 12a-c produces ethyl alph...
International audienceThe reaction of 1H-pyrazolo[3,4-d]pyrimidin-4,6-dithione 11 with compounds 12a...
The chemical synthesis and biological evaluation of some acyclic alpha-[6-(1'-carbamoylalkylthio)-1H...
Some compounds, analogous to those found in naturally occurring systems, are found to possess chemo...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
Several pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one ribonucleosides were prepared and tested fo...
A new series of pyrazole 4–7 and pyrazolo[1,5-a]pyrimidine 8–13 were synthesized by usin...
A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues h...
Pyrazolo[1,5-c]pyrimidines are biologically active, synthetically useful and important heterocyclic ...
Optically pure acyclic nucleoside analogues with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dih...
3(5)-Carboxamido-4-(beta-D-ribofuranosyl)pyrazoles bearing 2-benzamido (15) and 3-mesyloxy (29) isos...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
International audienceThe synthesis of novel acyclic nucleosides in the 5-alkynyl and 6-alkylfuro[2,...
Herein we describe a class of unconventional nucleosides (methyloxynucleosides) that combine unconve...
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R$\sb{\...