Topics
2-aminopyridineChemical substance
formaldehydeChemical substance
IsatinChemical substance
aminothiazoleChemical substance
AZTChemical substance
piperidineChemical substance
Isatin/5-substituted Isatin was reacted with 2-aminothiazole, 2-aminopyridine, 4-methoxyaniline to form Schiff bases and the N-Mannich bases of the above Schiff bases were synthesized by reacting with formaldehyde and piperidine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR data and elemental analysis. Investigation of Anti-HIV activity was done against replication of HIV-1 (III B) and HIV-2 (ROD) in MT-4 cells. Azidothymidine (AZT) was used as the reference standard. The most active compound of the series was 3-(2-thiazolylimino)-5-bromo-1,3-dihydro-indol-2-one (VI) which demonstrated 28% and 10% protection against HIV-1 and HIV-2 respectively.status: publishe
The derivatives of isatin have already been known to display a variety of biological activities. The...
The human immunodeficiency virus (HIV) is the etiological agent of the acquired immunodeficiency syn...
The isatin derivatives, Schiff bases, were synthesized by the reaction of isatin and various substit...
Isatin (Indole 2,3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-methylmercap...
Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4'-pyri...
Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopy...
Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by conden...
A series of 3-3-2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihy...
A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dih...
Objective: Acquired immunodeficiency syndrome (AIDS) was first identified in the Western world in 19...
A series of 3-3-2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihy...
A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were s...
A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives...
The human immunodeficiency virus (HIV) is the etiological agent of the acquired immunodeficiency syn...
The derivatives of isatin have already been known to display a variety of biological activities. The...
The derivatives of isatin have already been known to display a variety of biological activities. The...
The human immunodeficiency virus (HIV) is the etiological agent of the acquired immunodeficiency syn...
The isatin derivatives, Schiff bases, were synthesized by the reaction of isatin and various substit...
Isatin (Indole 2,3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-methylmercap...
Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4'-pyri...
Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopy...
Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by conden...
A series of 3-3-2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihy...
A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dih...
Objective: Acquired immunodeficiency syndrome (AIDS) was first identified in the Western world in 19...
A series of 3-3-2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihy...
A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were s...
A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives...
The human immunodeficiency virus (HIV) is the etiological agent of the acquired immunodeficiency syn...
The derivatives of isatin have already been known to display a variety of biological activities. The...
The derivatives of isatin have already been known to display a variety of biological activities. The...
The human immunodeficiency virus (HIV) is the etiological agent of the acquired immunodeficiency syn...
The isatin derivatives, Schiff bases, were synthesized by the reaction of isatin and various substit...
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