Clinical Implementation of NIPT - Technical and Biological Challenges
- Brady, Paul
- Brison, Nathalie
- Van Den Bogaert, Kris
- de Ravel de l'Argentière, Thomy
- Peeters, Hilde
- Van Esch, Hilde
- Devriendt, Koenraad
- Legius, Eric
- Vermeesch, Joris
Publication date
May 2016
DOI Publisher
Wiley-Blackwell Publishing, Inc. Journal
1399-0004Abstract
Non-invasive prenatal testing (NIPT) for fetal aneuploidy detection is increasingly being offered in the clinical setting. Whereas the majority of tests only report fetal trisomies 21, 18 and 13, genome wide analyses have the potential to detect other fetal, as well as maternal, aneuploidies. In this review we discuss the technical and clinical advantages and challenges associated with genome wide cell free fetal DNA profiling.status: publishe
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