Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: possible implications for radiotherapy treatment planning strategies
- Bollineni, Vikram R
- Koole, Michel
- Pruim, Jan
- Brouwer, Charlotte L
- Wiegman, Erwin M
- Groen, Harry J M
- Vlasman, Renske
- Halmos, Gyorgy B
- Oosting, Sjoukje F
- Langendijk, Johannes A
- Widder, Joachim
- Steenbakkers, Roel J H M
Publication date
November 2014
DOI Publisher
Elsevier Science Publishers ISSN
0167-8140 Journal
issn:1879-0887 Citation count (estimate)
37Abstract
To define the optimal time point for the integration of hypoxia (18)F-FAZA-PET/CT information into radiotherapy treatment planning to benefit from hypoxia modification or dose escalation treatment. Therefore, we performed a prospective cohort study, using serial hypoxic imaging ((18)F-FAZA-PET/CT) prior to and at several time-points during (chemo)radiotherapy (CHRT) in six head and neck squamous cell (HNSCC) and six non-small cell lung cancer (NSCLC) patients.status: publishe
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