Add to ORKGWhen primary rabbit kidney cell cultures are treated with either polyadenylic acid-polyuridylic acid or polyadenylic acid-polyribothymidylic acid (poly(rT)) and then judiciously exposed to actinomycin D and cycloheximide, high titers of interferon are found in the extracellular medium ("superinduction") (Vilcek, J. (1970) Ann. N. Y. Acad. Sci. 173, 390-403; Tan, Y. H., Armstrong, J. A., Ke, Y. H., and Ho, M. (1970) Proc. Natl. Acad. Sci. U. S. A. 67, 464-471). If polyinosinic acid is added 1 hour prior to, simultaneously with, or 1 hour after the active interferon inducers, dramatic reductions in interferon production from the "superinduced" cells result. Based on experiments involving sucrose gradient ultracentrifugation, pancreatic ribonu...
ABSTRACT Polyribocytidylate-3 H-polyriboinosinate (rC-3H:rI) enters cul-tured rabbit kidney cells fr...
After a first exposure to single-stranded polyriboinosinic and polyribocytidylic acids, which initia...
Interferon treatment has become a well-established form of therapy, in collaboration with chemothera...
Poly(xanthylic acid) [X)n] abolished the ability of (A)n-(U)n to induce interferon in "superinduced"...
The interferon-inducing activity of the double-stranded complex poly(A) - poly(U) in primary rabbit ...
Experimental conditions necessary for the full expression of interferon-inducing activity by a compl...
Although poly(I) is generally considered to be inactive as an interferon inducer, we have found seve...
Although poly(I) is generally considered to be inactive as an interferon inducer, we have found seve...
Interruption of the (I)n strand of (I)n.(C)n by unpaired bases [(U)] yielded mismatched analogues, (...
A large variety of displacement reactions between homopolynucleotides and complexes thereof has been...
Poly(inosinic acid).poly(cytidylic acid) [(I)n.(C)n] duplexes of which the (C)n strand was modified ...
The antiviral activity and interferon-inducing ability of single-, double-, and triple-stranded poly...
Synthetic double-stranded ribopolynucleotides are inducers of interferon, a protein which increases ...
Complexes of poly(C) with copolymers of inosinic acid containing various amounts of mismatched bases...
Interferon-treated L cells exhibit a specific enhanced susceptibility to the cytotoxic and interfero...
ABSTRACT Polyribocytidylate-3 H-polyriboinosinate (rC-3H:rI) enters cul-tured rabbit kidney cells fr...
After a first exposure to single-stranded polyriboinosinic and polyribocytidylic acids, which initia...
Interferon treatment has become a well-established form of therapy, in collaboration with chemothera...
Poly(xanthylic acid) [X)n] abolished the ability of (A)n-(U)n to induce interferon in "superinduced"...
The interferon-inducing activity of the double-stranded complex poly(A) - poly(U) in primary rabbit ...
Experimental conditions necessary for the full expression of interferon-inducing activity by a compl...
Although poly(I) is generally considered to be inactive as an interferon inducer, we have found seve...
Although poly(I) is generally considered to be inactive as an interferon inducer, we have found seve...
Interruption of the (I)n strand of (I)n.(C)n by unpaired bases [(U)] yielded mismatched analogues, (...
A large variety of displacement reactions between homopolynucleotides and complexes thereof has been...
Poly(inosinic acid).poly(cytidylic acid) [(I)n.(C)n] duplexes of which the (C)n strand was modified ...
The antiviral activity and interferon-inducing ability of single-, double-, and triple-stranded poly...
Synthetic double-stranded ribopolynucleotides are inducers of interferon, a protein which increases ...
Complexes of poly(C) with copolymers of inosinic acid containing various amounts of mismatched bases...
Interferon-treated L cells exhibit a specific enhanced susceptibility to the cytotoxic and interfero...
ABSTRACT Polyribocytidylate-3 H-polyriboinosinate (rC-3H:rI) enters cul-tured rabbit kidney cells fr...
After a first exposure to single-stranded polyriboinosinic and polyribocytidylic acids, which initia...
Interferon treatment has become a well-established form of therapy, in collaboration with chemothera...