Cinchona alkaloid induced chiral discrimination for the determination of the enantiomeric composition of α-trifluoromethylated-hydroxyl compounds by \u3c sup\u3e 19 \u3c/sup\u3e F NMR spectroscopy

The determination of the enantiomeric composition of α- trifluoromethylated-hydroxyl compounds using cinchona alkaloids as chiral selectors is described. The interaction between the alkaloid and trifluoromethylated-hydroxyl compounds converted the enantiotopic nuclei to diastereotopic nuclei observed by 19F NMR spectroscopy. A wide variety of target molecules have been studied to highlight the broad applicability of the method. © 2005 Elsevier Ltd. All rights reserved