Add to ORKGParkinsons disease is a common, disabling brain disorder in which neurodegeneration leads to a variety of motoric and non-motoric symptoms. Loss-of-function mutations in PARK2, the gene encoding theE3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinsons disease (PD). Parkin translocates from the cytosol to depolarized mitochondria, ubiquitinates outer mitochondrial membrane proteins and induces selective autophagy of the damaged mitochondria (mitophagy). Parkin may thus be neuroprotective by mediating the removal of dysfunctional mitochondria which would otherwise lead to increased oxidative stress and induction of apoptosis. The identification of a deubiquitinating enzyme (DUB) that counteracts Parkin could lead t...
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disea...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by mitochondrial ...
The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in famili...
Parkinson s disease is a common, disabling brain disorder in which neurodegeneration leads to a vari...
Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most ...
Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most ...
Mutations in the gene for the E3 ubiquitin ligase Parkin are the most common cause of recessive Park...
Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (P...
itin E3 ligase parkin impacts various cellu-lar processes including the autophagic clearance of defe...
Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiqui...
An accumulation of damaged mitochondria by reactive oxygen species (ROS) can trigger apoptosis. This...
Abstract Background Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Pa...
Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous stud...
doi:10.1111/febs.13249 Mutations in the parkin or PINK1 genes are the leading cause of the auto-soma...
Abstract Mitochondrial autophagy or mitophagy is a key process that allows selective sequestration a...
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disea...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by mitochondrial ...
The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in famili...
Parkinson s disease is a common, disabling brain disorder in which neurodegeneration leads to a vari...
Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most ...
Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most ...
Mutations in the gene for the E3 ubiquitin ligase Parkin are the most common cause of recessive Park...
Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson's Disease (P...
itin E3 ligase parkin impacts various cellu-lar processes including the autophagic clearance of defe...
Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiqui...
An accumulation of damaged mitochondria by reactive oxygen species (ROS) can trigger apoptosis. This...
Abstract Background Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Pa...
Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous stud...
doi:10.1111/febs.13249 Mutations in the parkin or PINK1 genes are the leading cause of the auto-soma...
Abstract Mitochondrial autophagy or mitophagy is a key process that allows selective sequestration a...
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disea...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by mitochondrial ...
The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in famili...